The UK Dementia Research Institute (UK DRI) is committed to transforming the lives of people affected by neurodegenerative conditions. We are seeking to appoint two Group Leaders (Principal Investigators) who will drive a visionary programme of experimental and translational research in any area of neuroscience relevant to dementia and neurodegeneration while also contributing to our collaborative and inclusive scientific community. As part of a distributed national MRC institute, these posts will be based at the UK DRI at Cardiff University with the ability to collaborate across sites

As a UK DRI Group Leader, you will lead an internationally competitive research programme. All areas of neuroscience will be considered, but we are keen to receive applications with experimental approaches that use mouse genetics and physiology, organoids, human-to-mouse chimeric models or human tissue. We welcome applications focussing on molecular, cellular or systems neuroscience, including glial biology, neural circuits and neuron-glia and gliovascular interactions. You will contribute to an integrated, collaborative, interdisciplinary, and open science environment. The UK DRI will provide support to enable the rapid translation of the fundamental insights gained into drug development and tangible benefits for people living with neurodegenerative conditions.

Applications are welcome from those seeking independence for the first time, as well as from established tenured researchers from the UK and abroad. The primary criteria for evaluation will be recent research excellence, scientific vision and potential for collaborative research across the UK DRI.

Key details

Closing date: 7 May 2026
Location: Cardiff

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