Job Title: Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Details of the role:

Reporting to: Charles Swanton, Principal Investigator, Deputy Clinical Director

Contact term: This is a full-time 2 year position on Crick terms and conditions of employment.

Salary for this Role: From £45,500 with benefits, subject to skills and experience

Application Closing date: 31st of December 2025 at 23.59

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for a creative and enthusiastic Postdoctoral Project Research Scientist to join the C Swanton Cancer Evolution and Genome Instability Laboratory.

This lab studies how cancers evolve in the body to spread and become resistant to therapy and discovers new ways to treat them more effectively. The research highlights that tumours consist of diverse groups of genetically related cancer cells, some of which adapt to resist treatments like chemotherapy, immunotherapy, radiotherapy, and targeted therapy. This resistance makes recurrent cancers more difficult to treat, particularly in diseases such as lung cancer.

The Project

As a PPRS you will investigate the role of cell lineage upon lung cancer initiation, both in homeostasis and in the context of challenge with non-mutagenic carcinogens. You will seek to understand which cells within the lung are most susceptible to air pollutants and the routes they take to tumourigenesis. By identifying common pathways across different lineages, you will aspire to identify actionable targets suitable for therapeutic intervention to prevent the onset of cancer. Additionally you will contribute to research which is committed to advancing our understanding of the biology of lung tumour evolution.

You will need to have a creative approach to research with wet lab competencies, and encourage applicants with wet and dry lab skills to apply. As Postdocs may lead projects, collaborate across teams and partners, and support PhD students, it is essential yo have strong communication and collaboration skills.

What you will be doing

To be a successful PPRS for this role, you will need:

• To decipher evolutionary mechanisms during lung cancer initiation and progression using data from animal models.

• To employ novel informatics techniques based on evolutionary principles to the analysis of tumour subclonal evolution.

• To understand cancer biology and the relevant literature sufficiently to take own ideas forward as lead author on new projects.

• To work within the informatics team of the TRACERx and TRACERx EVO programs.

• To record all experiments and code in an accurate timely, clearly presented and reproduceable manner

• To contribute to the dissemination of scientific results by means of writing papers for publication and presentations.

Workday Enterprise Systems Manager

Details of the role

Working pattern: Monday – Friday: This is a full time permanent hybrid role on Crick terms and conditions of employment.

Salary: From £60,805 with benefits, subject to skills and experience

Application closing date: 4th of January 2026 at 11.59pm

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

Join Us as a Workday Enterprise Systems Manager!

Are you a Senior Workday Developer or Technology Lead looking for your next big challenge? Passionate about driving value through cutting-edge enterprise technology? If so, we’ve got an exciting opportunity that could be the perfect next step in your career.

We're looking for a Workday Enterprise Systems Manager to join the team and play a pivotal role within the IT Operations team, to ensure that Workday continues to provide value and ROI. You will take ownership of Workday platforms and shape its future, whilst delivering real impact, leading innovation and transforming how our organisation works.

You'll also have the opportunity to build custom applications and create impactful proofs of concept (PoCs) that drive real innovation across the business whilst also having the opportunity to focus on innovation, including development of automation and AI, which is key to this role.

As a Workday Enterprise Systems Manager, you will be joining a team of enterprise systems colleagues working across functions to manage and enhance how Workday supports organisational processes and customer experience for colleagues. You will have the change to collaborate with other members of the ITO team, as well as the People and Finance team and beyond.

What you will be doing

As a Workday Enterprise Systems Manager at the Crick, you will:

• Ensure Workday alignment with business needs and priorities, and IT strategic objectives (collaborating with colleagues in IT Operations (ITO) People and Finance) by capturing, assessing and prioritising improvements across People and Finance, ensuring agile sprints are delivered on time, within scope, and budget in line with business objectives. Manage competing demands from.

• Manage all aspects of the implementation, configuration, and optimisation of all Workday modules working with cross-functional colleagues to create the detailed designs, define technical specifications, and develop delivery plans.

• Ensure robust development practices, including coding standards, testing, and documentation, are following and continuously improved through regular lessons learned/ retrospective exercises, e.g. in accordance with ITIL best practices. Awareness of GDPR, considering and managing related risks.

• Monitor health, usage, and overall compliance of Workday and its applications

• Create and / or maintain internal technical documentation and manuals with regards to Workday processes and automation tasks

• Monitor and resolve escalated BAU issues, providing advanced technical troubleshooting, root cause analysis, and continuous improvement.

About you

You will bring

• Strong hands-on Workday development and configuration experience in one or more modules (e.g., HCM, Core HR, Financials, Absence, Security, Integrations) including using AI and automation. Solid understanding of business processes in.*

• Demonstrable experience in system integration, platform development, and change delivery in an enterprise context. Knowledge of large-scale data uploads.*

• Workday Security Model: Experience managing domains, security groups, and role-based access controls.

• Workday Integrations: Proficiency with EIBs, Core Connectors, Workday Web Services (WWS). API & Web Services: Understanding of REST/SOAP APIs, JSON, and XML for integration work.*

• Change Control & QA: Experience with peer reviews, structured testing, deployment practices, and environment management.

• Familiarity with Agile or iterative delivery methods.*

• Benchmarking & Innovation: Awareness of Workday roadmap, emerging features, and innovation opportunities.*

*Minimum Requirements

About Working at the Crick

Our values  

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture

• We are

  bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.

• We are

  open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.

• We are

  collegial. We show respect for one another, work cooperatively and support the wider community.

Job Title: Research Management Administration Officer (Scientific Discourse)

Details of the role:

Working pattern: Monday – Friday. Peak activity during recruitment cycles may require occasional early starts, evenings or short periods of flexible working. This is a full-time, hybrid (3 days a week) permanent position on Crick Terms and Conditions of Employment

Salary: From £45,350 with benefits, subject to skills and experience

Application closing date: 11th of January at 23.59

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for an organised and pro-active Research Management Administration Officer to join our Research Management support team.

This role plays a vital role in sustaining the Crick’s scientific culture by leading lectures, seminars, symposia, and other key events that showcase diverse scientific exchange.

Working closely with the Assistant Research Director and Communications team, you’ll ensure these activities are effectively planned, delivered, and promoted. You’ll take ownership of discourse events end to end, while contributing to faculty retreats and advisory board meetings. The role also supports group leader recruitment, coordinating symposia, interviews, and candidate visits to integrate them into the wider programme of scientific dialogue.

We’re looking for someone with strong event experience, a passion for science, and ideally some recruitment knowledge, who can build relationships, bring energy, and deliver world class events.

What you will be doing

As a Research Management Officer at the Crick, you will:

Scientific discourse

• Lead the Crick’s scientific discourse activities, including Crick Lectures, Insight Lectures, Annual Science Meeting, Annual Technology Meeting, Medicine at the Crick, Interest Groups and Crick Conferences.

• Coordinate invitations, logistics, scheduling, itineraries, publicity, travel, and on-the-day delivery for high-profile speakers and events.

• Coordinate and work closely with committees responsible for discourse (e.g. Lecture Committee, ASM Committee, Conferences Committee), working closely with the ARD for Scientific Discourse.

• Maintain an integrated events calendar to ensure coherence and diversity of speakers and disciplines, and track expenditure against discourse budget codes (the postholder is not a budget holder).

Group leader recruitment

• Support and coordinate group leader recruitment symposia, chalk talks, and interview events, ensuring professional delivery and strong faculty engagement.

• Assist with candidate itineraries for seminar and chalk talk visits, reimbursements and visitor experience.

• Support onboarding of successful candidates with a focus on integration into the Crick’s scientific community and discourse culture.

Job Title: Enterprise Systems Lead – ServiceNow (Mat cover)

Details of the role:

Working pattern: Monday – Friday. This is a 12 month (Mat cover) fixed term position on Crick terms and conditions of employment. This role is hybrid and requires a minimum of 3 days per week in the office.

Salary: From £59,700 with benefits, subject to skills and experience

Application closing date: 4th of January 2026 at 23.59

About us  

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for an engaging and passionate Enterprise Systems Lead – Service now to join our team here at the Crick. This is a pivotal role where you will participate in the design, development, and ongoing improvement of enterprise platforms and integrated systems that support the Crick’s needs and ambitions.

You will be a proactive leader with strong organisational skills, stakeholder engagement experience, and a solid understanding of the design and development lifecycle. You’ll bring hands on experience with ServiceNow or similar ITSM platforms, guiding developers and driving process improvements. As this role involves significant project management, you will bring energy and creativity to foster positive team collaboration. You will be a strong listener who takes the time to understand stakeholder needs and effectively translate them into clear actions for the team.

What you will be doing

You will:

• Leading the delivery of design, implementation and service transition for products and services using the current enterprise systems platforms (focused on ServiceNow, but may also include Workday, particularly where scope includes both platforms)

• Working with other leads within ITO to prioritise work packages for the Enterprise systems team

• Working with Application Owners and external vendors to design and support workflows to support operations and science processes.

• Supporting the Head of Enterprise Systems to develop processes and ways of working that support the strategic vision of ITO including automation, documentation, modularisation and reuse.

• Implement integration solutions that connect various enterprise applications and systems.

• Utilise ServiceNow integrations platform (e.g. Flow Designer) to create, streamline, and automate processes.

Job Title: Laboratory Research Scientist – Part time

Details of the role:

Reporting to: Head of Genomics Science Technology Platform

Contract Term: This is a part-time (2 days per week) 12-month fixed-term contract on Crick terms and conditions of employment.

Salary: From £36,535 (pro-rata) with benefits subject to skills and experience

Application closing date: 11th of January 2026 at 23.59

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for an experienced part time Laboratory Research Scientist to join the Genomics Science Technology Platform at the Francis Crick Institute.

The Genomics Science Technology Platform delivers cutting‑edge Next Generation Sequencing (NGS) services, from sample intake and QC to library prep and sequencing, enabling world‑class biomedical discoveries.

About the Project

This team supports over one hundred research groups and runs a wide spectrum of genomic technologies, including Illumina, Oxford Nanopore, 10x Genomics, and spatial genomics. They support bulk NGS (RNA‑seq, ATAC‑seq, whole genome/exome), single‑cell sequencing, and spatial profiling to unlock deep biological insights. In this role, you’ll help deliver these services, lead workflows, and collaborate to expand capacity and knowledge sharing.

In this part‑time role (2 days per week), you will enjoy a flexible schedule, ideal if you are returning to the workforce or balancing other commitments. You will bring a keen eye for detail, a strong background in molecular biology, and a solid understanding of genomics workflows. With this expertise, you will play a key role in ensuring operational excellence and keeping our cutting‑edge facility running seamlessly.

What you will be doing

As a LRS at the Crick, you will:

• Proactively provide reliable cross-covering support across the spectrum of work in the Genomics STP. This includes sample submission, and independent execution or support of workflows, for example nucleic acid extractions, quality control, bulk and single-cell library preparation, and spatial assays.

• Confidently operate automated liquid handling platforms for high-throughput work.

• Monitor QC metrics and implement corrective actions where needed to maintain consistent high data quality.

• Work collaboratively and within our project management framework to ensure timely processing of samples and efficient turnaround for researchers.

• Help to implement new technologies and methods in collaboration with colleagues.

• Optimise and troubleshoot workflows, contributing to continuous improvement and increased efficiency across platforms.

• Provide clear, concise, and timely communication with team members, stakeholders, and scientific collaborators.

• Keep up to date with the latest developments in the field and proactively cascade relevant information via appropriate channels.

• Maintain high standards of data integrity and record-keeping using electronic laboratory notebooks and LIMS.

• Ensure adherence to SOPs and contribute to their development and documentation.

• Participate in equipment and lab maintenance schedules ensuring operational readiness.

• Closely adhere to health and safety requirements

Senior Laboratory Research Scientist Pharmacologist

Reports to: Pharmacology Expert, PLRS, Chemical Biology STP

Both roles are full-time fixed term positions on Crick terms and conditions of employment

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for two Senior Laboratory Research Scientists to join the Chemical Biology Science Technology Platform at the Crick. The Chemical Biology STP collaborates with researchers at the Crick to apply chemistry to explore biological questions, working at the cutting edge of biomedical science in disciplines such as cancer, infectious disease, immunology, neurology, and developmental biology.

We are seeking a creative and driven molecular pharmacologist, with expertise in a range of in vitro assays technologies and their application in early drug discovery projects. As an SLRS, you will contribute to establishing of state-of-the-art screening approaches for the identification and optimisation of chemical modulators of protein targets.  Furthermore, the role will require in-depth knowledge of approaches to link the mechanism of probes or drugs to the treatment of disease.

This role presents the opportunity to build on the capabilities being built in the Chemical Biology STP, in collaboration with Screening and Automated Science and Structural Biology STPs, to influence translational science at the Crick. This will be prosecuted through lab-based contributions as pharmacology/assay lead on early drug discovery teams, as well as the provision of pharmacology and drug discovery consultancy on nascent translational projects.

What you will be doing:

Some of your key responsibilities will include:

• Close collaboration with colleagues in aligned STPs (including SAS, Structural Biology, Proteomics, NMR) to continue to establish state-of-the-art cross-STP screening approaches for hit identification, validation and optimisation against novel targets.
• Proactive suggestions of suitable assay technologies that enable the selection of potential probes and therapeutics.
• Application of these approaches to Crick translational projects, advising on screening strategy for new targets and supporting the development of assays for compound screening.
• Contribution to interdisciplinary drug discovery teams as a molecular pharmacologist, taking accountability for the development of complex biological assays and the elucidation of mechanism of action.
• Scientific leadership as an assay area expert; staying abreast of the latest literature and developments in the field; and driving technology projects that optimise/modernise the current drug discovery process.

This position may be appointed at a Principal Senior Laboratory Research Scientist level, for applicants who demonstrate the skills and substantial relevant experience.

We are also recruiting for an ambitious and creative biochemical assay scientist, with drug discovery experience to join the STP. This exciting project is a collaboration focusing on the translation of cutting-edge research led by Dr. Simon Boulton and carried out in the Double Strand Break (DSB) Metabolism Laboratory. You will play an integral part of the ongoing drug discovery project to identify, characterise and optimise chemical tools for the newly identified ALT-synthetically lethal targets.

Alternative Lengthening of Telomeres (ALT) is one of two mechanisms by which cancer cells solve the “End Replication Problem” and achieve immortality. ALT positive cancers respond poorly to standard chemotherapies, making them amongst the most difficult to treat. Approximately 15% of all characterised cancers are ALT positive but, to date, there has been little specific drug development. Researchers in the DSB Metabolism Laboratory have genetically identified several proteins that are synthetically lethal in cancer cells that rely on ALT for maintenance of their telomere length.

In collaboration with the ALT project team, you will contribute to the elucidation of detailed molecular mechanism of action of these new chemical tools and work with disease-area biologists to translate these findings into more biologically relevant systems. In parallel, you will work with medicinal and computational chemists to help optimise the chemical tools into candidate-quality molecules, designing assay systems to inform on structure activity relationships and drive compound optimisation. Finally, you will work together with the biophysics and structural biology team members to gain mechanistic insights into the new ALT targets.

What you will be doing:

Some of your key responsibilities for this role will include:

• Development and optimisation of biochemical assays, utilising fluorescence, luminescence or absorbance technologies for compound screening.
• Ensuring routine biochemical compound screening is carried out to a high standard.
• Timely and thorough capture of all assay data in the ALT project Dotmatics ELN.
• Design and implementation of detailed mechanistic studies to characterise inhibitor mode of action.
• Contribute to establishment of MS-based reactive fragment and NMR fragment screening pipelines at the Crick.

Job descriptions

In your application, please state which role out of the two you are interested in applying for.

Senior Laboratory Research Scientist Pharmacologist

Reports to: Pharmacology Expert, PLRS, Chemical Biology STP

Both roles are full-time fixed term positions on Crick terms and conditions of employment

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for two Senior Laboratory Research Scientists to join the Chemical Biology Science Technology Platform at the Crick. The Chemical Biology STP collaborates with researchers at the Crick to apply chemistry to explore biological questions, working at the cutting edge of biomedical science in disciplines such as cancer, infectious disease, immunology, neurology, and developmental biology.

We are seeking a creative and driven molecular pharmacologist, with expertise in a range of in vitro assays technologies and their application in early drug discovery projects. As an SLRS, you will contribute to establishing of state-of-the-art screening approaches for the identification and optimisation of chemical modulators of protein targets.  Furthermore, the role will require in-depth knowledge of approaches to link the mechanism of probes or drugs to the treatment of disease.

This role presents the opportunity to build on the capabilities being built in the Chemical Biology STP, in collaboration with Screening and Automated Science and Structural Biology STPs, to influence translational science at the Crick. This will be prosecuted through lab-based contributions as pharmacology/assay lead on early drug discovery teams, as well as the provision of pharmacology and drug discovery consultancy on nascent translational projects.

What you will be doing:

Some of your key responsibilities will include:

• Close collaboration with colleagues in aligned STPs (including SAS, Structural Biology, Proteomics, NMR) to continue to establish state-of-the-art cross-STP screening approaches for hit identification, validation and optimisation against novel targets.
• Proactive suggestions of suitable assay technologies that enable the selection of potential probes and therapeutics.
• Application of these approaches to Crick translational projects, advising on screening strategy for new targets and supporting the development of assays for compound screening.
• Contribution to interdisciplinary drug discovery teams as a molecular pharmacologist, taking accountability for the development of complex biological assays and the elucidation of mechanism of action.
• Scientific leadership as an assay area expert; staying abreast of the latest literature and developments in the field; and driving technology projects that optimise/modernise the current drug discovery process.

This position may be appointed at a Principal Senior Laboratory Research Scientist level, for applicants who demonstrate the skills and substantial relevant experience.

We are also recruiting for an ambitious and creative biochemical assay scientist, with drug discovery experience to join the STP. This exciting project is a collaboration focusing on the translation of cutting-edge research led by Dr. Simon Boulton and carried out in the Double Strand Break (DSB) Metabolism Laboratory. You will play an integral part of the ongoing drug discovery project to identify, characterise and optimise chemical tools for the newly identified ALT-synthetically lethal targets.

Alternative Lengthening of Telomeres (ALT) is one of two mechanisms by which cancer cells solve the “End Replication Problem” and achieve immortality. ALT positive cancers respond poorly to standard chemotherapies, making them amongst the most difficult to treat. Approximately 15% of all characterised cancers are ALT positive but, to date, there has been little specific drug development. Researchers in the DSB Metabolism Laboratory have genetically identified several proteins that are synthetically lethal in cancer cells that rely on ALT for maintenance of their telomere length.

In collaboration with the ALT project team, you will contribute to the elucidation of detailed molecular mechanism of action of these new chemical tools and work with disease-area biologists to translate these findings into more biologically relevant systems. In parallel, you will work with medicinal and computational chemists to help optimise the chemical tools into candidate-quality molecules, designing assay systems to inform on structure activity relationships and drive compound optimisation. Finally, you will work together with the biophysics and structural biology team members to gain mechanistic insights into the new ALT targets.

What you will be doing:

Some of your key responsibilities for this role will include:

• Development and optimisation of biochemical assays, utilising fluorescence, luminescence or absorbance technologies for compound screening.
• Ensuring routine biochemical compound screening is carried out to a high standard.
• Timely and thorough capture of all assay data in the ALT project Dotmatics ELN.
• Design and implementation of detailed mechanistic studies to characterise inhibitor mode of action.
• Contribute to establishment of MS-based reactive fragment and NMR fragment screening pipelines at the Crick.

Job descriptions

In your application, please state which role out of the two you are interested in applying for.

Senior Research Scientist – Santos Lab 

Reports to: Silvia Santos, Group Leader

This is a full-time, 1 year fixed term

position on Crick terms and conditions of employment

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the research group

The Quantitative Stem Cell Biology lab, headed by Dr Silvia Santos, was established in 2018 at the Francis Crick Institute. The lab’s primary focus is understanding cell decision-making. Current areas of research include understanding regulatory mechanism regulating cell fate specification, cell cycle remodeling during cellular differentiation and the interplay between metabolism, cell cycle and cell fate. There is a strong focus on single cell analysis and advanced live cell imaging. The lab uses a variety of model systems: mouse and human embryonic stem cells (ESC), 3D organoid models of mouse and human development and mouse embryos.

The team is multi-disciplinary, diverse and currently composed of three PhD students, two post-doctoral fellow and one principal laboratory research scientist. The Santos lab promotes independent and creative thinking and all members are committed to providing excellent training and mentorship.

For more information on the Quantitative Stem Cell Biology lab please see: