About us
The UK Dementia Research Institute (UK DRI) is a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.
Dementia is the biggest health challenge of our century – currently affecting over fifty million people worldwide, projected to triple by 2050, with huge financial, emotional and social impact on people directly affected, their carers, families and the community.
About the role
The Bourdenx lab is recruiting a Research Fellow to investigate mechanisms of vulnerability to proteostasis collapse in ageing and neurodegenerative disorders. Our research integrates spatial and single cell omics, and computational approaches to understand why specific neuronal populations selectively degenerate in dementia.
You will join a team of researchers working on the project “Disentangling the diverse forms of collective protein homeostasis in neuronal condensates” in collaboration with Professor Jernej Ule’s team at King’s College London.
You will focus on molecular and cell biology techniques, including the generation, maintenance and characterisation of novel iPS cells, their differentiation into neurons, as well as the direct differentiation of fibroblasts to neurons. Functional studies will involve high-content imaging, sequencing technologies and proteomics.
This post is available immediately and is funded by the Medical Research Council for one year in the first instance.
For informal enquiries about the role please contact Dr Mathieu Bourdenx (m.bourdenx@ucl.ac.uk).
About you
You will have a PhD in Molecular or Cellular Biology, or a related discipline, with experience with iPSC culture or direct conversion of fibroblasts, and genome-editing techniques. Experience in advanced scientific programming for bioinformatics or spatial biology (Python, R) and programming good practices (version control, etc), in microscopy and image acquisition, and molecular biology are also a requirement, as is knowledge of neuroscience related themes. Knowledge of biology of ageing and experience with cell culture and biochemistry (western blot, IP, etc) are desirable.
Key details
- Location UK DRI at UCL
- Salary: £43,981-£52,586 per annum
- Lab: Dr Mathieu Bourdenx