About the role:
Dr Sarah Marzi https://ukdri.ac.uk/team/sarah-marzi) is seeking to appoint a Research Associate. Her research programme aims to determine the role of epigenetic regulation in neurodegenerative diseases, Parkinson’s and Alzheimer’s disease, using state of the art epigenetic and genomic techniques in cell populations and at the single cell level. We are seeking a postdoctoral researcher to work on epigenetic and transcriptional profiling of toxicant exposures and Parkinson’s in cell and animal models as well as postmortem human brain tissue.
The successful candidate should have laboratory experience in epigenetics techniques, particularly chromatin profiling. Prior experience in single cell genomics approaches is essential. You will be a dynamic, creative, and motivated scientist interested in pursuing questions deeply. With strong molecular biology experience of genomic/epigenomic approaches, you will use a range of methods for cell and brain tissue analyses including next generation RNA sequencing, ChIP sequencing and CUT&Tag (or equivalent) and ATAC sequencing methods, and particularly 10X single cell multiome profiling.
The Marzi Lab is highly collaborative. You will join a multidisciplinary team on the Denmark Hill Campus with a leading role in:
- Designing and performing experiments
- Developing technical advances
- Performing data analysis
- Presenting the results
- Writing up manuscripts to be submitted to peer-review journals
About you:
To be successful in this role, we are looking for candidates to have the following skills and experience:
Essential criteria
- Hold a PhD in Molecular Biology, Neuroscience or a closely related discipline, or equivalent research, industrial or commercial experience
- Practical experience within a research environment and publication in relevant and refereed journals and ability to conduct a detailed review of recent literature
- Knowledge of gene regulation and chromatin biology, particularly in the context of neurodegenerative diseases.
- Practical experience in a broad range of standard laboratory techniques including light microscopy and molecular biology (e.g., immunofluorescence on brain tissue, cloning, qPCR, cell culture
- Practical experience single cell or single nuclear genomics methods, including experience with dissociation protocols from low input material
- Excellent written communication skills and the ability to write clearly and succinctly for publication
- Willingness to work as part of a team and to be open-minded and cooperative
- Practical experience with epigenetic assays, including any of the following:
- ChIP-seq
- ATAC-seq
- CUT&Tag
Desirable criteria
- Experience working with bio-banked tissue
- Familiarity with neuroanatomy and/or immunology
- Knowledge of Parkinson’s disease genetics and neurobiology
Key details
- Location UK DRI at King's
- Salary: £45,031 - £52,514 per annum