Research Assistant-Translational Pharmacology and Immunology Laboratory (TPI)
Research Assistant-Translational Pharmacology and Immunology Laboratory (TPI)
- Posted 09 April 2026
- Salary Grade 6 £33,951 - £37,694 per annum
- LocationGlasgow
- Job Type Research and Teaching
- Reference196713
- Expiry 07 May 2026 23:45
Job description
Job Purpose
The Translational Pharmacology and Immunology Laboratory (TPI), headed by Professor Maria Libera Ascierto, is at the heart of translational & experimental cancer research and clinical biomarker discovery at the University of Glasgow (UofG). Based in the School of Cancer Sciences, the TPI is the driver of biomarker development and clinical application, mainly in support of clinical trials enrolling patients visiting the Beatson West of Scotland Cancer Centre.
The TPI also acts as a central laboratory for processing, storage and analysis of samples derived from patients enrolled in clinical trials of novel therapies sponsored by pharmaceutical companies.
Major professional responsibilities of the post holder are to support translational studies in accordance with Good Clinical Practice (GCP), and led by Prof Maria Libera Ascierto, that are aimed to process human samples derived from patients, including clinical trial participants, and assess them by using ex-vivo immunological assays (eg Immunogenicity Assays to measure immune cell activation, proliferation, and cytokine production, Drug Toxicity and Efficacy assays and Cell Function Monitoring) and spectral cytometry evaluations to boost in-dept-immune phenotype of peripheral blood and disaggregated tumours, monitor disease progression, treatment response and appropriate treatment dosage of novel clinical trials and immune-oncology (IO) treatments.
The main duties & responsibilities of the post-holder are dependent on (1) the specific project or clinical trial and (2) the biomarker strategy and design under the direction of Prof Maria Libera Ascierto. These, in turn, may be in response to the requirements and objectives that emerge from the Glasgow Adult ECMC and CRUK CDD’s investigators.
Main Duties and Responsibilities
1. Plan and conduct assigned research activities based on spectral cytometry to assist with research project and business operations requiring biological sample, mainly whole blood, PBMC and digested tumours.
2. Responsible for performing and documenting ex vivo immunological assays (eg Immunogenicity Assays to measure immune cell activation, proliferation, and cytokine production, Drug Toxicity and Efficacy assays and Cell Function Monitoring) in accordance with TPI procedures and regulatory guidelines.
3. Document research outputs including sample information, analysis and interpretation of all data, maintaining records and databases, drafting technical/progress reports and manuscript as appropriate.
4. Support the safe transport, handling, processing, storage and analysis of biological specimens derived from patients enrolled in clinical trials according to Good Clinical Practice (GCP) and under the supervision of TPI Head. Take responsibility for following and maintaining Clinical and Research Governance protocols, monitoring compliance and escalating matters for further management attention as appropriate.
5. Develop, optimize and standardize multicolour (up to 40 colours) - flow cytometry immune panels for clinical trials samples evaluations.
6. Contribute to Corrective and Preventive Action (CAPA) experimental investigations, deviations, and resolutions as appropriate.
7. Responsible for performing and documenting flow cytometry and spectral cytometry analytical procedures in accordance with TPI procedures and regulatory guidelines.
8. Assists in troubleshooting and process improvements to increase data quality, lower costs, or reduce turnaround times to include, updating standard procedures, assisting with troubleshooting.
9. Performs and documents calibration and maintenance of laboratory Flow Cytometry and additional equipment as assigned.
10. Performs and documents hands on training for other lab personnel in areas of proven competency as assigned.
11. Assist the TPI Head in the development of proposals to secure funding from internal and external bodies to support future research based on immune phenotype.
12. Collaborate with colleagues and participate in group meetings/seminars/workshops organized by TPI /School/College/University and wider community, including the ECMC Network.
13. Contribute to the organisation, supervision, mentoring and training of undergraduate and/or postgraduate students and less experienced members of the project team to ensure their effective development in spectral cytometry and flow cytometry.
14. Perform administrative tasks related to the activities of the Flow TPI research group, Budgets/Expenditure.
15. Keep up to date with current knowledge and recent advances in the field/discipline.
16. Engage in continuing professional development activities as guided by the TPI Head.
17. Perform all of the above-mentioned activities, and undertake any other duties of equivalent standing, in conjunction with and under the guidance of the Translational Pharmacology and Immunology Head, Prof Maria Libera Ascierto.
18. Contribute to the enhancement of the international profile of the TPI in line with the University’s Strategic Plan, World Changers Together
Knowledge, Qualifications, Skills and Experience
Knowledge/Qualifications
Essential:
A1 SCQF Level 10 (Honours degree) in Biology, Immunology or equivalent.
A2 Records of appropriate GCP and GCLP trainings to ensure public safety.
A3 A comprehensive and proven knowledge of biomarker discovery and application using whole blood cells and tumour digests
Skills
Essential:
C1 Proven knowledge of processing and storage of blood and tumour cells samples according to GCP standards and suitable for downstream flow cytometry assessments and ex-vivo immunological assays
C2 Research creativity and cross-discipline collaborative ability as appropriate
C3 Excellent communication skills (oral and written), including public presentations and ability to communicate complex data/concepts clearly and concisely
C4 Excellent interpersonal skills including team working and a collegiate approach
C5 Appropriate workload/time/project/budget/people management skills
C6 Extensive IT and data analysis/interpretation skills as appropriate
C7 Self-motivation, initiative and independent thought/working
C8 Problem solving skills including a flexible and pragmatic approach
Experience
Essential:
E1 Proven experience in translational medicine research experience in spectral cytometry performed on human samples
E2 Proven experience in translational medicine research experience in spectral cytometry or conventional flow data analysis using R software, and/ or FlowJo
E3 Proven experience in GCLP settings or CRO providing Flow cytometry services using high quality standards (eg. Q2 solutions)
E4 Proven ability to deliver quality outputs in a timely and efficient manner
E5 Proven ability to deliver ex-vivo immunological assays performed on human samples (eg Immunogenicity Assays to measure immune cell activation, proliferation, and cytokine production, Drug Toxicity and Efficacy assays and Cell Function Monitoring)
E6 Evidence of an emerging track record of high-quality research publications in spectral cytometry immune- phenotype or a a relevant field(eg conventional Flow Cytometry)
Informal enquiries should be directed to Professor Maria Ascierto, Maria.Ascierto@glasgow.ac.uk
Terms and Conditions
Salary will be Grade 6, £33,951 - £37,694 per annum.
This post is full-time (35 hours per week) and has funding available for up to 12 months in first instance.
Please note this post will be 100% based in lab, with no possibility of hybrid working.
The University of Glasgow has a responsibility to ensure that all employees are eligible to live and work in the UK. If you require a Skilled Worker visa to work in the UK, you will be required to meet the eligibility requirements of the visa route to be assigned a Certificate of Sponsorship.
Please note that this post may be eligible to be sponsored under the Skilled Worker visa route if tradeable points can be used under the Skilled Worker visa rules. For more information please visit: https://www.gov.uk/skilled-worker-visa.
As a valued member of our team, you can expect:
1 A warm welcoming and engaging organisational culture, where your talents are developed and nurtured, and success is celebrated and shared.
2 An excellent employment package with generous terms and conditions including 41 days of leave for full time staff, pension - pensions handbook https://www.gla.ac.uk/myglasgow/payandpensions/pensions/, benefits and discount packages.
3 A flexible approach to working.
4 A commitment to support your health and wellbeing, including a free 6-month UofG Sport membership for all new staff joining the University https://www.gla.ac.uk/myglasgow/staff/healthwellbeing/.
We believe that we can only reach our full potential through the talents of all. Equality, diversity and inclusion are at the heart of our values. Applications are particularly welcome from across our communities and in particular people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented within the University. Read more on how the University promotes and embeds all aspects of equality and diversity within our community https://www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/.
We endorse the principles of Athena Swan https://www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/athenaswan/ and hold bronze, silver and gold awards across the University.
We are investing in our organisation, and we will invest in you too. Please visit our website https://www.gla.ac.uk/explore/jobs/ for more information.
Closing Date: 7 May 2026 at 23:45