PhD: Role lysosome dysfunction in MND
About the Project
This studentship aims to investigate how mutations associated with rare familial forms of motor neurone disease (MND), disrupt lysosomal function in human motor neurons. Using a combination of patient-derived fibroblasts and iPSC-derived motor neurons carrying MND-associated mutations the studentship will characterise the impact of the mutations on lysosomal morphology, acidification, and Ca2+ handling. Quantitative assays, including ratiometric fluorescent imaging and automated confocal analysis, will be used to assess lysosomal morphology, distribution and function. In parallel, we will evaluate downstream consequences such as altered proteolytic activity and lipid accumulation. The student will explore therapeutic rescue of lysosomal defects using small molecule modulators of lysosomal function. Through detailed mechanistic and phenotypic analyses, this studentship seeks to establish how lysosomal dysregulation contributes to MND and to identify potential therapeutic targets relevant to a broader spectrum of MND patients.
Lead Supervisor- Dr Owen Peter
Entry Requirements:
As only one studentship is available and a very high standard of applications is typically received, the successful applicant is likely to have a very good first degree (a First or Upper Second class BSc Honours or equivalent) and/or be distinguished by having relevant research experience.
How to apply:
You can apply online - consideration is automatic on applying for a PhD with an October 2026 start date.
Entry Requirements:
As only one studentship is available and a very high standard of applications is typically received, the successful applicant is likely to have a very good first degree (a First or Upper Second class BSc Honours or equivalent) and/or be distinguished by having relevant research experience.
This 3.5‑year studentship, funded by the Motor Neurone Disease Association, is available to 'Home' fee status applicants and will begin on 1st October 2026. The award covers tuition fees and provides a maintenance stipend, which is ££21,383, for the 2026/27 academic year.
Key details
- Location UK DRI at Cardiff
- Salary: This 3.5‑year studentship, funded by the Motor Neurone Disease Association, is available to 'Home' fee status. The award covers tuition fees and provides a maintenance stipend, which is ££21,383, for the 2026/7 academic year