Head of Enterprise Architecture

Head of Enterprise Architecture

• locations
• London

• posted on
• Posted Today

• job requisition id
• R-003162

Salary: £140,000

Closing date: 4 March 2026

Contract type: Permanent  

Interview dates: W/C 9 March 2026

The Wellcome Trust is a global charitable foundation. We improve health for everyone by funding science, leading policy and advocacy campaigns, and building partnerships.

We plan to spend £16bn over the next ten years, funding new discoveries in life, health, and wellbeing, and taking on three global health challenges: mental health, infectious disease and climate and health.

These challenges need the bold science we support, but they won’t be solved by science alone.

Wellcome Trust is seeking a Head of Enterprise Architect to lead and shape the organisation’s technology landscape, providing strategic guidance to the CIO, building an enterprise architecture capability, and driving simplification, governance, and innovation across all systems and data.”

Where in Wellcome will I be working?  

You will operate at enterprise level within Wellcome Trust, sitting at the heart of the organisation’s technology landscape. Helping shape the overall enterprise architecture across the organisation.

What will I be doing? 

You will be defining how technology works across the entire organisation, ensuring it is simplified, future-ready, well-governed, and aligned to Wellcome’s mission — while building the architecture capability from the ground up and advising at executive level.

Is this job for me?    

Do you have enterprise-level architecture experience and have you led strategic technology initiatives?

Have you worked in cross-functional teams, influencing senior leadership or Board-level stakeholders?

Are you comfortable building a capability from scratch and shaping processes and governance?

Minimum Criteria: 

• Proven experience implementing enterprise architecture strategies and building architecture capabilities.

• Familiarity with TOGAF or equivalent architecture standards.

• Ability to assess, assure, and improve the control environment across technology systems.

• Experience leading teams, managing budgets, and building high-performing, inclusive functions.

• Strong technical understanding across multiple domains: applications, data, integration, emerging technologies (AI/ML).

You can view the full Job Description on our website  

You can read more about the benefits we offer our employees on our website   

Our Hybrid Way of Working  

We understand that our colleagues have commitments and personal interests outside of work and we strive to build a flexible working environment, in which people can perform at their best.

At Wellcome we have a hybrid way of working which is 3 days in our Euston Road offices (Tuesday, Wednesday and Thursday) with the remaining 2 days working either remotely or in the office.

Diversity and Inclusion is at the heart of everything we do  

Diversity and Inclusion is a priority at Wellcome. We are committed to cultivating a fair and inclusive environment, where everyone can be themselves and thrive. We are happy to discuss flexible working options for all roles. We work to ensure that our recruitment processes are as inclusive as possible to everyone. This includes making adjustments for people who have a disability or long-term condition.

 Please visit our  website for more information on adjustments and accessibility, or contact us at 

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jobs@wellcome.org

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About Us

We support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research. Wellcome isn't just a supporter of great ideas, it's a great place to work. We offer excellent benefits and help our employees to develop in an open, respectful culture where differences are valued.