Senior Postdoctoral Fellow

• locations
• Hinxton, Cambridgeshire

• time type
• Full time

• posted on
• Posted Today

• job requisition id
• JR103394

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

We are seeking a talented and motivated Senior Computational Postdoctoral Fellow to lead the analysis for Project JAGUAR, a landmark multi-country initiative generating one of the world’s most comprehensive single-cell immune transcriptomic resources from diverse Latin American ancestries. This 3-year role sits at the heart of an equitable, international consortium focused on scientific discovery, capacity building, and inclusive collaboration. You will play a key role in advancing large-scale single-cell analysis, shape analytical strategy, and lead a distributed and equitable analysis model involving partners across seven Latin American countries. This position offers a rare chance to work at global scale in a project that is as much about science as it is about capacity building, equity, and reshaping international collaboration. You will work closely with local teams, contribute to training and shared analytical development, and help steward a model that empowers researchers across the region to lead future genomic initiatives.

If you are excited by big data, global partnerships, and impactful questions at the heart of human diversity and immune regulation, we would love to hear from you.

What you'll be doing?

• Overseeing the end-to-end analysis of a multimillion-cell PBMC scRNA-seq dataset

  
  

• Developing and optimising pipelines for QC, integration, clustering, annotation, and cell-state modelling

  
  

• Performing genetic and ancestry-aware analyses, including regulatory variant mapping and donor-level modelling

  
  

• Coordinating and mentoring analysts across Latin America, ensuring coherent, high-quality, and equitable analytical contributions

  
  

• Driving joint interpretation, reporting, and publication of consortium findings

  
  

• Developing scalable workflows and documentation to support consortium-wide training, reproducibility, and knowledge sharing

  
  

• Contributing to strategic planning for downstream analyses, extensions, and cross-modal integration

About Us:

Project JAGUAR is a major collaborative effort between the

at the Wellcome Sanger Institute, and partner institutions across seven Latin American countries. The project is a unique, first-of-its-kind effort designed to close a major gap in global genomics research by creating a deeply characterised single-cell cohort representing the rich ancestry diversity of Latin America.

Trynka Group

We have generated millions of immune single-cell profiles using scRNA-seq, scATAC-seq, CITE-seq profiling, and enriched with genotyping, ancestry inference, and general health questionaire metadata. Our collaborative analysis framework is co-developed with analysts in Latin America, ensuring equitable contributions, shared ownership, and long-term capacity building. This model is transforming how international genomics collaborations are designed and delivered. Our goal is to understand how genetic variants and ancestry shape immune function, and to provide a foundation for more equitable and globally representative human genomics.
 

About You:
You are passionate about scientific discovery and a creative computational scientist with documented experience in leading large scale genomics analysis and a strong interest in single-cell biology, population genetics, and immune regulation. You thrive in collaborative environments, enjoy working across countries and cultures, and take pride in building analytical frameworks that empower others. You bring scientific rigor, curiosity, and the capacity to coordinate complex, distributed projects with clear communication and a supportive approach.Essential Skills:

● Demonstrable experience with single-cell RNA-seq analysis, including QC, integration, clustering, and
annotation
● Proficiency in Python and/or R for large-scale data analysis
● Experience developing reproducible workflows, pipelines, and scalable data-processing frameworks
● Knowledge of population genetics, ancestry inference, or genetic association analyses
● Experience working with high-dimensional datasets and statistical modelling
● Demonstrated ability to lead complex analysis projects and coordinate work across multiple partners or teams
● Proven ability to work independently and deliver research projects
● Excellent communication skills with experience engaging diverse and multicultural research teams
● Experience training, mentoring, or supporting junior analysts or collaborators
● Interest in contributing to capacity building and equitable international science
● PhD in computational biology, bioinformatics, statistical genetics, genomics, or a related field
● Publication record demonstrating experience in high-quality computational research
● Proven ability to develop and maintain effective working relationships with wide range of persons of
differing levels, abilities and knowledge
● Foster an inclusive culture where all can thrive and diversity is celebrated
● Demonstrated mentorship, supervision and leadership abilities
● Detailed orientated, strong organisational and problem-solving skills
● Commitment to open, inclusive, and equitable scientific practice
● Demonstrating working proactively
● Ability to creatively solve analytical challenges
Other Information:

For further information, please see role profile.

Salary per annum (dependent upon skills and experience): £43,650 - £49,156

Closing Date: 4th January 2026

Application Process:

Please apply with your CV and a Cover letter outlining how you meet the criteria set out above.

Interviews to be held in late January 2026.

Hybrid Working at Wellcome Sanger:

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion:

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018.  The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.

About Us

Life at the Sanger Institute is unique. We are tackling some of the most difficult challenges in genomic research. Our people are shaping the future by delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges. We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world.

Benefits

We offer an attractive benefits package at the Wellcome Sanger Institute. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.

Visa Sponsorship

Each year, the Wellcome Sanger Institute welcomes researchers from around the world to the Genome Campus to collaborate and drive cutting-edge science. Whether you're joining as faculty, a postdoc, or a visitor, our dedicated International Team offers expert guidance and support throughout your journey, promoting the Institute’s global and collaborative ethos.