About us

Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.

The Busche Laboratory, based in the UK DRI at UCL, is a highly interactive environment, with strong collaborations across the UK DRI as well as with researchers at UCL and other renowned institutions.

About the role

We are seeking an exceptional individual to join on a cutting-edge research programme aimed at understanding - and ultimately reversing - neuronal and circuit dysfunction in Alzheimer’s disease.

The focus will be on linking early, cell-type-specific molecular alterations to large-scale neural circuit impairments in mouse models. The project will combine spatial omics methods with advanced techniques to record neuronal activity across large populations of cells, such as in vivo two-photon calcium imaging. A variety of experimental and analytical approaches will be applied to interrogate the mechanisms of dysfunction.

This is an outstanding opportunity to work independently on a high impact, state-of-the-art project in a stimulating, vibrant research environment.

The role is available from 01 February 2026 and funded by the UK Dementia Research Institute until 31 January 2028 in the first instance.

Informal enquiries regarding the role can be addressed to Dr Marc Aurel Busche (m.busche@ucl.ac.uk).

About you

You will hold a PhD in neuroscience, engineering, computer science, mathematics, physics, or a related field, and prior practical experience with spatial transcriptomics and related data processing/analysis. Expertise in modern molecular biology techniques such as AAV design and validation, immunostaining and confocal microscopy, single-cell RNA sequencing, quantitative in situ hybridization, and related bioinformatic skills, experience in rodent stereotactic surgery are essential for the role. Excellent interpersonal, collaboration, and communication skills are also required.

This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.

Key details

• Location UK DRI at UCL
• Salary: £43,981-£52,586
• Lab: Dr Marc Aurel Busche